Economic diplomacy is one of the most important tools in the service of a country's foreign policy, which can lead to economic prosperity and increase the power and influence of a country in the global and regional arena. Examining the indicators of economic diplomacy including export, import, and foreign investment in the last decade indicates that the country's conditions in this field have fluctuated and sometimes declined. The continuation of this situation, while reducing Iran's regional power and influence, will reduce the trends leading to economic prosperity within the country; as a result, it is necessary to analyze the policymaking pathology of economic diplomacy in order to overcome the current situation. Accordingly, the fundamental question arises: what are the most important policy damages to Iran's economic diplomacy in the last decade? The provisional answer to this question is as follows: The lack of serious attention to the issue of lifting and neutralizing sanctions, the lack of a grand strategy based on interdependence with the global economy, especially with its neighbors, and the lack of a documented operational strategy based on the use of trade opportunities are the most important damages in the policymaking arena of Iran's economic diplomacy. The research method in this article is descriptive-analytical and it has been used to collect data and information from library and internet sources as well as official statistical sources in Iran and the world.